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A clinical trial of a NOS inhibitor (546C88) was terminated early because of unexpected numbers of deaths in the group that received the drug.70 Thus, caution maybe needed in the use of blanket inhibition of NO, CO, or H 2 S as this may well have unintended consequences

They concluded that systemic application of BPC-157 did not alter blood circulation in healthy gingiva, and chronic application of the peptide had potent anti-inflammatory effects on periodontal tissues in ligature-induced periodontitis in rats