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First, by inhibiting system Xc , Erastin causes a drastic reduction in GSH levels, leading to the inactivation of GPX4 and the accumulation of lipid peroxides, thus inducing and amplifying ferroptosis

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It has been shown along with the triglyceride tributyrin to regulate cytokine levels, eliciting strong anti-inflammatory effects

A competitive GST P1-1 assay was performed to identify the inhibition type of these five compounds

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