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Essential Roles of Local Auxin Biosynthesis in Plant Development and in Adaptation to Environmental Changes

ADHD drugs such as clonidine and guanfacine, as well as the dopamine agonist Pramipexole, were once touted as potential nootropics, only to be marred later by null findings when tested for cognitive enhancement in healthy individuals

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While the majority of these approaches have been validated primarily in preclinical animal models, several have established safety profiles in human trials for other indications: MitoQ has completed Phase II trials for Parkinsons disease and hepatitis C with favorable safety outcomes (Zhang H

doi: 10.1371/journal.pone.0119578

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