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Currently, most studies on PSMs focus on efficacy validation, while systematic evaluations of chronic toxicity, reproductive toxicity, carcinogenicity, and other aspects are insufficient

However, it decreased hepatic insulin extraction and, as a result, increased insulin half-life (352)

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Nat Genet (1995) 10(1):1113.10.1038/ng0595-111 90 GilbodySLewisSLightfootT

Thus, as before in the occlusion-like syndrome studies or in the Budd-Chiari (suprahepatic inferior caval vein occlusion) occlusion-syndrome [13,22,23,24,25], there was direct blood delivery from the inferior caval vein to the superior caval vein to break the vicious cycle instantly

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