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Importantly, basal HO-1 expression levels, rather than HO-1 levels after oxPAPC treatment, strongly correlated negatively with the expression of proinflammatory cytokines such as IL-6 ( r = 0.36, p = 1.37 e 06), IL-8 ( r = 0.28, p = 2.41 e 04), CAMs such as VCAM1 ( r = 0.22, p = 3.31 e 03), UPR such as Activating factor (ATF)3 ( r = 0.40, p = 5.01 e 08)

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As a result, the analyses reported here are restricted to the TBS-soluble fraction where other changes could be present in the TBS-insoluble fraction

Although glucagon-like peptide-1 (GLP-1) activation is reported to ameliorate oxidative stress by increasing antioxidant levels, the administration of TIR with DXN did not significantly mitigate the effects of DXN on induced cognitive impairment and oxidative stress

INTER-PATIENT VARIABILITY IN PEDIATRIC APAP PHARMACOLOGY TOXICITY AND EFFICACY Acetaminophen is generally well tolerated, making it an attractive choice for the treatment of fever and pain in the pediatric population