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Prokinetic agents such as metoclopramide or domperidone, which accelerate gastric emptying, may counteract some of the therapeutic effects of semaglutide on satiety and weight loss

Therefore, in patients with renal or hepatic insufficiency (or both), arginine is generally avoided or only administered with extreme caution under close monitoring

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Areas under investigation include: Cellular signaling pathways Tissue remodeling processes Angiogenesis-related signaling Extracellular matrix interactions Cellular migration and organization Because biological systems are highly complex, no single mechanism fully explains the observations reported across different studies

And, certainly, continue the traditional therapies