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104 Tryptophan and its derivative, 5-hydroxytryptophan (5-HTP), have been used to treat depression, anxiety, and sleep disorders, 103,105 and higher dietary tryptophan intake was linked to lower risk of depression and increased self-reported sleep duration in an observational study with 29,687 participants

W., and Li, S

The most effective skin tightening treatments are those that target the skins deep supporting collagen fiber network to cause tightening up of the existing fibers and growth of new fibers

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doi: 10.5114/ada.2021.108896

If you choose to combine them, its a good idea to start with moderate doses of each and monitor how your body responds