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Notably, all patients had previously been treated with pentosan polysulfate, which is currently the only FDA approved treatment for interstitial cystitis, and had not responded

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In contrast, LDNs display a functionally exhausted phenotype, with reduced chemotactic and immune functions, impairing their ability to eliminate pathogens and necrotic cells [84]

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Oncotarget (2017) 8:5782635