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ARA-290 has demonstrated: Regeneration of small nerve fibers Improvement in autonomic symptoms Reduced neuropathic pain Sarcoidosis-Associated Neuropathy In inflammatory conditions such as sarcoidosis, ARA-290 has been shown to: Reduce nerve inflammation Improve pain and fatigue Support nerve recovery Kidney Protection Because erythropoietin signaling plays a role in renal protection, ARA-290 has been studied for: Reducing renal inflammation Limiting ischemic kidney injury Preserving tubular function Autoimmune and Inflammatory Conditions Although not a classic autoimmune therapy, ARA-290s ability to calm inflammatory signaling makes it relevant in conditions characterized by immune-mediated tissue injury

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NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinsons disease

Anetzberger GJ, Palmisano BR, Sanders M, et al