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The overt phenotype of the mutant mice and blood counts were not significantly different from wildtype (Supplementary Fig

They have a role in various signaling cascades, such as response to growth factor stimulation and control of inflammatory responses [25]

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doi: 10.3389/fmed.2023.1122529 149 TurnerSKhanMAPutrinoDWoodcockAKellDBPretoriusE

The tip of the microvilli is always relatively hypoxic compared to the base, and in reduced perfusion states, oxygen will tend to move down a gradient from arteriole to venule closer to the base, thus exacerbating hypoxia at the tip and potentially switching apoptosis to necrosis in epithelial cells

were the first to show that oral administration of Lactobacillus engineered to express full-length GLP-1 (137) could induce intestinal epithelial cells to transdifferentiate into insulin-producing cells, restoring up to 33% of normal insulin secretory activity