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Then -catenin binds to a protein called TrCP (beta-transducin repeat containing protein) that mediates the ubiquitination of CTNNB1 and the proteins tagged with ubiquitin are degraded by the proteosome that results in -catenin destruction by the proteosomal degradation

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The network diameter of the whole Wntsignaling network in which these three sub-networks are integrated, is found to be 15

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