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Potential concerns include effects on angiogenesis that theoretically could influence tumor development or progression, though preclinical studies show context-dependent effects that inhibit pathological angiogenesis in some tumor models

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Ethics All animal experimental protocols in this study were approved by the University of Zurich Animal Protection Office and Ethics committee, the Cantonal Veterinary Office of the Canton of Zurich (licences n 102/2018 and 136/2021), and conform to Swiss Animal Protection guidelines and regulations (Swiss Animal Protection and Swiss Animal Act and Ordinance) and in accordance with the EU Directive on the protection of animals used for scientific purposes

2016;11(6):e0156742