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Once the sealing ability is disrupted and marginal leakage occurred this consequently ends up with restoration failure [19, 20]

The secretion of IL-25 by tuft cells can also be modulated by the SCFA, succinate, produced by members of the intestinal microbiota, particularly species of the Bacteroidetes phylum who are prolific producers of this metabolite (Connors et al

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Several lysine residues lie within the sequence near these loops and conceivably would provide the amino groups for cross-linking
