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[DOI] [PubMed] [Google Scholar] 56.Norris S.R., Barrette T.R., DellaPenna D

It could also reverse the destructive action of oxygen radicals and excitatory amino acids.813 Several authors have described the potential deleterious effects in the neonate of antenatal exposure to MgSO4, including hypotonia, respiratory depression, an increased need of neonatal resuscitation and intubation,14,15 cardiac failure,16 lower 1-min and 5-min Apgar scores,12,14 intraventricular haemorrhage17 or a higher rate of admission to the neonatal intensive care unit.18 However, other studies have not found an association between antenatal exposure to MgSO4 and these adverse events.1922 One of the most controversial potential complications of MgSO4 described in the literature is meconium obstruction, and the evidence to date has been contradictory

For instance, a systematic review of lifestyle interventions for PCOS adolescents identified major changes in both anthropometric and clinical parameters

In conclusion, we developed ENDOs, small-molecule inhibitors of endolysosomal signaling that block the Munc13-4STX7 interaction to attenuate inflammation
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