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J Clin Pharmacol 47:430444 Hirsh AJ, Molino BF, Zhang J, Astakhova N, Geiss WB, Sargent BJ, Swenson BD, Usyatinsky A, Wyle MJ, Boucher RC, Smith RT, Zamurs A, Johnson MR (2006) Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis

This work was supported by a Grant-in-Aid for JSPS Specially Promoted Research (21000005), Platform for Drug Discovery, Informatics and Structural Life Science from MEXT, Japan, and the Life Science Research Fund of Takeda Science Foundation to H.S., a Grant-in-Aid for JSPS Fellows to K.I

07 Label and refrigerate Write the reconstitution date on the vial

It is a natural regulator of various cellular pathways in skin regeneration

2 Methodology 2.1 Literature search strategy A comprehensive literature search was conducted to collect relevant information on the ethnopharmacology, geographical distribution, traditional medicine, bioactivity, phytochemistry, pharmacology, and toxicology of Stevia