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ATP7A-LINKED NEURODEGENERATIVE DISORDERS Unlike AT7B, where mutations in the gene result in a single known clinical phenotype (Wilson disease), mutations in ATP7A cause three X-linked neurodegenerative diseasesMenkes disease, occipital horn syndrome (OHS), and X-linked distal hereditary neuropathy (dHMN) (Kaler, 2011)

Conlon MA, Tomas FM, Owens PC, et al

The measurement of lipid peroxidation markers and redox status over time would be helpful in evaluating AD progression [60]

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These findings suggest that copper overload causes impairment of the antioxidant defense system in several tissues

Clin Transl Immunol