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Compared with the urolithiasis model group, the ferroptosis agonist, erastin, significantly increased the relative expression of ACSL4, TF and TRC, and reduced that of XCT and GPX4

Schwaitzberg SD, Roberts K, Romanelli JR, Desilets DJ, Earle D, Horgan S,

Mechanistically, impaired FR-mediated folate uptake disrupts C1 metabolism, reducing methylation capacity and altering the expression of genes critical for synaptic formation, neuronal excitability, and neurotransmitter metabolism

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