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Study C4591001 (Study 2) is a Phase 1/2/3, multicenter, multinational, randomized, saline placebo-controlled, observer-blind, dose-finding, vaccine candidate-selection (Phase 1) and efficacy (Phase 2/3) study that has enrolled approximately 46,000 participants, 12 years of age or older

Not everyone experiences first-week improvements

Regulation of inflammation: Regulates excessive inflammation but does not dampen the signals for repair

Inflammation traps iron in storage cells

The effect of the others on pain suppression awaits further study

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