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The time to current activation was unaffected by 100 M TMAO (Figures 10G,H), suggesting little modulation of this channel complex or, similar to data in Figure 4, alterations to ATP synthesis, given this channels role as an ATP sensor (Brennan et al., 2024

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In the latest international pooled analysis, the adverse associations of TMAO with certain cardiometabolic biomarkers have been elucidated, and the mechanisms of action, independent of renal function, warrant further investigation ( Publisher's Note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study