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Genetic testing revealed heterozygous gene variants in MC1R and CDKN2A, a highrisk melanomaassociated gene

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The chemical structure, particularly the amine head group, significantly influences mRNA encapsulation and delivery efficiency [39]

The prevalence rate of sporadic lesions is 2%8% in Caucasians, with a melanoma relative risk ranging from 1.6 (95% confidence interval [CI] 1.41.8) for subjects with one dysplastic nevus to 10.5 (95% CI 5.121.8) for subjects with five or more dysplastic nevi.(4) Familial-type dysplastic syndrome was classified by Kraemer as: Type B for individuals with a family history of dysplastic nevi

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