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This work was supported by JSPS KAKENHI (Grant Number: 16K14468) and Mochida Memorial Foundation for Medical and Pharmaceutical Research

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These aldehydes modify critical proteins via adduct formation, alter intracellular signaling, and promote the activation of NF-B and other pro-inflammatory pathways [34,35], which exacerbate local inflammation and contribute to the systemic oxidative burden observed in psoriatic patients [36]