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Individuals with specific single nucleotide polymorphisms (SNPs) impacting B12 absorption may benefit more from certain forms of Vitamin B12. However, since these SNPs are not typically included in commercial tests, individuals may need to experiment with different B12 forms sequentially or opt for a supplement containing a combination of all three naturally occurring forms of B12 for potentially faster clinical improvements

This type of study is important for several reasons: it tells us how long the peptide remains active in the body, what breakdown products are formed (which could themselves have biological activity or be used as markers in drug testing), and helps explain why AOD9604 needs to be administered in certain ways to remain effective

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