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DOXY targets the 30S ribosomal subunit of Mycoplasma , inhibiting protein synthesis and prolonging peptide chains, which suppresses the growth and replication of drug-resistant strains, alleviates symptoms, shortens disease duration, and improves clinical outcomes 2,3

Aging as a key modulator of ferroptosis susceptibility Advanced age is the most significant non-modifiable risk factor for major cognitive disorders, including AD, PD and DACI (98-100)

Abbreviations AAT aspartate aminotransferase Ala alanine ALAT alanine aminotransferase APOE apolipoprotein E Asp aspartate BCAA branchedchain amino acid BCAT branchedchain amino acid aminotransferase BCKA branchedchain keto acid CaMKII Ca 2+ /calmodulindependent protein kinase II alpha EAAT excitatory amino acid transporter GABA aminobutyric acid GABAT GABA transaminase GAD glutamate decarboxylase GAT GABA transporter GDH glutamate dehydrogenase GHB hydroxybutyrate GLAST glutamate aspartate transporter 1 GLT1 glutamate transporter1 Glu glutamate GS glutamine synthetase iPSC induced pluripotent stem cell LAT Ltype amino acid transporter MAS malateaspartate shuttle NMR nuclear magnetic resonance OAA oxaloacetate PAG phosphateactivated glutaminase PC pyruvate carboxylase PDH pyruvate dehydrogenase Pyr pyruvate ROS reactive oxygen species SLC solute carrier SNAT sodiumcoupled neutral amino acid transporter SSADH succinic semialdehyde dehydrogenase TCA tricarboxylic acid (cycle) KG ketoglutarate 1

Essays Biochem 60(3):275301

E.LiuY.ZhangY.JaramilloC

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