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Hu and co-workers also showed that the brain targeting efficiency was impacted by the types of phospholipids used in the preparation of liposomes [47]

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Genetic studies have now identified a single mutation of a highly conserved cysteine in transmembrane 5 of Glut9, C188F, as the mutation causing both liver urate uptake and renal reabsorption defects (103)

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Most patients benefit from continuous use, as collagen production and skin quality improve progressively over time