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Preclinical data and clinical observations point to potential in chronic inflammatory conditions (like IBD) , persistent joint injuries, and even neuroprotective support

This suggests the essential role of the p53/TIGAR axis in mediating the effects of UA, leading to a reduction in glycolytic potential

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FDR p = 0.003), kynurenic acid (r = 0.56

Liu et al (63) recently elucidated the molecular mechanism by which lactate regulates hepcidin expression and, consequently, systemic iron homeostasis