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Combined nicotinamide N-methyltransferase inhibition and lean-diet substitution reduces body weight and liver fat in obese mice

Body weight considerations The Phase 2 clinical trial used fixed doses regardless of body weight

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We suggested these particular effects and this background as a network of the evidence for the physiologic significance of the revealed BPC 157/vascular-system interplay [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41] (i.e., in situ hybridization and immunostaining studies in humans evidenced BPC 157 large distribution in tissues [102] and suggested its additional physiologic regulatory roles [8,102])