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Of note, the prespecified selection process based on the pharmacokinetic profile during the activity stage was ultimately consistent with the results observed at the efficacy stage, with numerically higher rates of ICU delirium in the high-dose melatonin group (66.7%) compared to the low-dose (54.4%) and control groups (56.0%)

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[DOI] [PubMed] [Google Scholar] 71.Lbban E., Ashor A., Shannon O.M., Idris I., Siervo M

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