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It acts as a primary line of defence against oxidative stress , which is the damage caused to cells by unstable molecules called free radicals

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This review consolidates epidemiological evidence linking SHG to these clinical endpoints and details the key underlying pathophysiological mechanisms by which SHG promotes NOAF, including inflammatory activation, oxidative stress activation, calcium handling dysfunction, and autonomic remodeling

The investigators concluded that administration of exogenous GSH had a beneficial effect on renal function by virtue of its antioxidant properties, and possibly by a vasodilator action to increase the glomerular filtration rate as well

In a subsequent mouse experiment, growing thiamine-deficient mice were supplemented with either thiamine or allithiamine up to 7 days