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Although studies suggested that tryptophan and its derivatives could influence the gut microbiome and interact with the gut mucosal immune system, recent clinical investigations proposed that changes in immunity and kynurenine metabolism may trigger fatigue in ME/CFS but do not sustain it over time [61, 67, 68]

Future studies with larger sample sizes will be needed to validate these findings and to enable more detailed modeling of potential period and carry-over effects

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PMID 15591001

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When discussing carbon chain length, fatty acids with 2-6 carbon atoms are termed short-chain fatty acids or SCFAs