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IGFBP-4 is specifically degraded by the metalloproteinase PAPP-A (Pregnancy Associated Plasma Protease -A) produced by the placenta as well as bone and ovary

Two-way ANOVA did not show an interaction between genotype and frequency, however, one-way ANOVA analysis of power in the gamma band (30100 Hz) shows that MK-801 increased gamma oscillatory power significantly more in GluN2C KO mice (224 32%) than in WT (62 25%