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The join algorithm was used to integrate all the chromatograms into a single data matrix using the following parameters: the balance between m/z and retention time was set at 10.0 each, m/z tolerance was set at 0.001 or 5 ppm, and retention time tolerance was defined as 0.5 min

For multi-dose vials, always clean the rubber top with a fresh alcohol swab before each use, even if you're the only person using it

The reason for this results from an anomaly due to a subtle quantum effect of the zero-point energies

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doi: 10.1016/S0304-3835(02)00090-3

Acknowledgements Cryo-EM data were collected at the University of Texas Southwestern Medical Center (UTSW) Cryo-Electron Microscopy Facility, funded in part by the Cancer Prevention and Research Institute of Texas (CPRIT) Core Facility Support Award RP170644