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We further demonstrated that an increase in urinary GSH concentrations during the formation of TLS is a common phenomenon in both mice and humans and proposed the utility of urinary GSH as a biomarker to detect TLS in the kidney

this was attributed to low UGT1A1 expression and T4 glucuronidation in carriers of the UGT1A1 rs8175347 allele

5 Metabolic and genetic alterations in gliomas Currently, the molecular basis and energy metabolism in gliomas are not fully understood

The authors reported a remarkable improvement in graft survival with preconditioned MSCs but not naive MSCs

The authors demonstrated that larger particles (5 m) caused more severe obstruction than smaller ones (2 m, 80 nm), suggesting size-dependent neurovascular toxicity

Cystine enters cells through system Xc- and is reduced to cysteine via the thioredoxin reductase 1 (TXNRD1)-dependent pathway and then contributes to GSH production (Fig