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These include the rule of exponents method, which uses maximum lifespan potential and brain weight to correct the exponent,15 liver blood flow,20 and correction for in vitro metabolic clearance.21 The method of choice will depend on the PK characteristics of the drug candidate and the data available for scaling

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However, nootropics work best alongside proven cognitive health strategies, such as regular exercise, a nutrient-rich diet, and mental stimulation

Transformative impact of nanocarrier-mediated drug delivery: overcoming biological barriers and expanding therapeutic horizons
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