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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability
Some patients may experience side effects while on Semaglutide
This makes it less likely to cause systemic side effects like water retention, insulin resistance, or abnormal growth of tissues
doi: 10.1074/jbc.M009093200 57 SmithRAJMurphyMP
Moreover, addressing B12 deficiency has shown promise in reducing symptoms, as supplementation can potentially stabilize mood and decrease anxiety levels
