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The role of the H 2-catalytic core interaction was assessed in human PLC 3, where point mutations in H 2 or its binding site on the catalytic core decreased the thermal stability of the enzyme and increased basal activity up to 50-fold over wild-type PLC 3 (Lyon et al., 2011)

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*Correspondence: Hamish M

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[DOI] [PubMed] [Google Scholar] 54.Lin J.Y., Selim M.A., Shea C.R., Grichnik J.M., Omar M.M., Monteiro-Riviere N.A., Pinnell S.R