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Meanwhile, Luciferase activity assays revealed no significant difference in GGCT promoter activity between Gln+ and Gln- groups, indicating that Gln does not directly regulate GGCT transcription (Fig

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These data suggest that increased GSH levels should have a positive effect on BP in hypertension, and we propose that pathological inhibition of vascular relaxation involves not only NO production by endothelial cells but also glutathione-dependent bioavailability of NO, with S-nitrosothiols playing an important role in the pathway

[PubMed] [Google Scholar] Mulcahy RT, Gipp JJ