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Puerarin mitigates ferroptosis by regulating iron-handling proteins, reducing lipid peroxidation via Nrf2 activation, and inhibiting COX-2, thereby protecting against iron overload-induced retinal degeneration [118]

80.2 Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M

Given its regulatory effects on immune signaling and inflammation, AMPK may play a role in modulating immunosenescence, although further studies are needed to elucidate this potential connection

Oxidative stress occurs when the formation of free radicals proliferates beyond what the bodys antioxidant defenses can handle

This synergy is exemplified by transmembrane protein 164 (TMEM164), which promotes autophagy-dependent ferroptosis in NSCLC
