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Puerarin mitigates ferroptosis by regulating iron-handling proteins, reducing lipid peroxidation via Nrf2 activation, and inhibiting COX-2, thereby protecting against iron overload-induced retinal degeneration [118]

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80.2 Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M

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Given its regulatory effects on immune signaling and inflammation, AMPK may play a role in modulating immunosenescence, although further studies are needed to elucidate this potential connection

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Oxidative stress occurs when the formation of free radicals proliferates beyond what the bodys antioxidant defenses can handle

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This synergy is exemplified by transmembrane protein 164 (TMEM164), which promotes autophagy-dependent ferroptosis in NSCLC

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