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The risk of bias was independently assessed by at least two investigators using of the adapted Downs and Black checklist, which is appropriate for both randomized and non-randomized studies ( Overview of study findings Study selection A total of 183 RCTs were inspected for eligibility, however, only 21 studies were selected, as shown in Figure 2

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It appears to be stable in gastric juice unusual for a peptide of this size which has driven interest in oral administration research models

Then, N,N-dimethyl-p-phenylendiamine sulfate (DPD, 20 mM) in HCl (7.2 M) and FeCl 3 (30 mM) in HCl (1.2 M) were added, and the absorbance of the solutions was measured at a wavelength of 650 nm