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The primary routes for permeation across the BBBinclude passive diffusion (lipid soluble solutes), ABC transporter efflux, carrier-mediated influx, and receptor-mediated transcytosis (Abbott et al., 2010)

Aging, inflammation, and disuse accelerate this decline: After stroke/SCI: Damaged pathways prevent voluntary activation.[11] In concussion/Long COVID: Neuroinflammation disrupts timing and coordination.[12] Post-injury: Pain guarding causes rapid atrophy (up to 1-2% muscle loss per day of immobilization).[13] The result

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zdemir et al., 2016