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Methylglyoxal, whose formation can reach 3 mg/kg body weight/day [230], is a glycating agent, forming mainly arginine-derived hydroimidazolone adducts, DNA adducts, and isomeric imidazopurinones [231]

Most studies follow people for just a few months , so we don't have solid long-term data yet

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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Taylor W.E., Bhasin S., Artaza J., Byhower F., Azam M., Willard D.H., Jr., Kull F.C., Jr., Gonzalez-Cadavid N