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The latter is quite stable, and may accumulate during GSH depletion, because GSH is needed to regenerate the selenolate ( pro

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These transcription factors subsequently activate the expression of Stearoyl-CoA Desaturase 1 (SCD1), which catalyzes the synthesis of long-chain monounsaturated fatty acids, such as oleic acid, thereby reducing the membranes susceptibility to oxidation and sensitivity to ferroptosis [119, 120]