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In addition, the mRNA expression of BMAL1 , PER2 , and CRY1 in visceral fat is closely related to the increase in waist circumference which is an indicator of metabolic syndrome ( The second is that the circadian clock system may control the rate-limiting steps of the metabolic process (Panda et al., 2002)

This indicates that MNP accumulation does not significantly induce or exacerbate inflammatory responses in the central nervous system

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