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Masaldan, S., Belaidi, A

This genetic condition results from the presence of an extra copy of chromosome 21, as first described by APP ) (Salehi et al., 2007), the Glutamate Receptor, Ionotropic, Kainate 1 ( GRIK1 ) (Valbuena et al., 2019), the Regulator of CAlciNeurin 1 ( RCAN1 ) ( Dual-specificity tyrosine phosphorylation-Regulated Kinase 1A ( DYRK1A ) (Nakano-Kobayashi et al., 2017

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Moreno-Fernandez ME, Giles DA, Oates JR, Chan CC, Damen M, Doll JR, et al

these include gastrointestinal problem 7 , sleep disorders 8 , immune system aberration 9 , neurotrophic factor dysregulation 10 , mitochondrial dysfunction 11 , and oxidative stress 12

Also, due to variations in immunogenicity among tumor cells, those with high immunogenicity trigger a strong anti-tumor immune response and are typically eradicated by the body