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Combination therapy may exert synergistic effects of drugs, improve treatment efficacy, and reduce the occurrence of adverse reactions

[DOI] [PubMed] [Google Scholar] 83.Schiattarella G.G., Hill J.A

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Differently, a marked depletion of GSH and ATP levels, accompanied by a profound increase in TBARS and ROS production, are associated with hepatocyte necrosis (Figure 4) [9]

Furthermore, glutathione is strictly required for Phase II liver detoxification, helping the body efficiently clear excess histamine and inflammatory cytokines from the bloodstream