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Sustained activation of the PERK-eIF2-ATF4 pathway has been strongly associated with EMT induction, survival under chemotherapeutic stress, and metastatic competence

10.1016/j.ejogrb.2017.04.042 [DOI] [PubMed] [Google Scholar] Dhamangaonkar P

Defective protein homeostasis in Nf1-deficient muscles Proteome analysis showed a significant downregulation of several components of the translational machinery, especially ribosomal proteins as well as tRNA synthases ( Figures 3A, 6A)

They found that biofilm can alter the mode of epithelial cells concerning oncogenic progression including decreased tumor suppressors, increased levels of inflammatory and angiogenic cytokines decrease in E-cadherin, and activation of IL-6, and STAT3 (Dejea et al

Exerc Immunol

PMID 3036131
