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Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis

However, H 2 O 2 can also lead to the production of the more damaging oxygen radical, OH , which can initiate a cascade of cellular injury through peroxidation of lipid, protein and DNA [24]

To further confirm Nrf2s involvement in the ER calcium regulation process via GPX8, in the same study, after silencing Nrf2 in HeLa cells, GPX8 mRNA and protein levels also decreased, resulting in elevated ER and cytosolic calcium levels at rest and increased histamine-induced ER calcium release (Granatiero et al., 2019)

clinicians should consult trial protocols, seek endocrinology input, and document clinical rationale with informed consent

10.1186/1710-1492-10-43 215 JiaL.XiaoL.FuY.ShaoZ.JingZ.YuanJ.et al

doi: 10.1371/journal.pone.0296733