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This, along with the high abundance of reduced glutathione, is consistent with glutathione playing a role as a scavenger for reactive metabolites, such as methylglyoxal, in some cancers, and exploiting this consequence of increased glucose metabolism could be a strategy to target FDG-PET avid cancers

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[DOI] [PMC free article] [PubMed] [Google Scholar] [138].Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM

By neutralizing free radicals, glutathione helps maintain healthy liver function

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