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An association is established between oxidative stress conditions and the augmentation of an inflammatory state in pathophysiology, regulated by the oxygen- and redox-sensitive pleiotropic cytokines.

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This study elucidates the role of the glutathione pathway in tracheal regeneration with aortic allografts, demonstrating its antioxidant-driven modulation of immune responses, extracellular matrix remodeling, and epithelial integration, advancing airway tissue engineering.