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5-EPIFAT trial protocol: a multi-center, randomized, placebo-controlled trial of the efficacy of pharmacotherapy for fatigue using methylphenidate, bupropion, ginseng, and amantadine in advanced cancer patients on active treatment

Subsequently, H 2 O 2 is further transformed into the highly reactive OH via the Fenton reaction, which requires the presence of reduced iron or copper ions (Halliwell and Gutteridge 1990)

It has also been believed by scientists that increasing our muscles store of carnitine is now considered as one of the most effective methods to increase fat metabolism during prolonged moderate-intensity exercise

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The upregulated genes were enriched in phosphorylation and signal transduction, while the downregulated genes were enriched in organismal development, morphogenesis, and transcription (Figure S6)

Across all sensitivity analyses in both cohorts, the strength and direction of the association between CTI and outcomes showed minimal variation, strongly supporting the robustness of the primary findings