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Many companies use synthetic fillers, artificial colors, or flow agents (like magnesium stearate) to make manufacturing easier

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These alterations include cross-linking, oxidation, fragmentation, peroxide formation, amino acid isomerisation, unfolding, and alterations to protein solubility (9698, 131134)

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Although macrophages are the main infiltrating cells, other cells contribute to the development of lesions including dendritic cells (84,85), mast cells, T cells, and B cells (Figure 1) (86,87)

Soffietti, R